Preprint / Version 1

The genus Porana (Convolvulaceae) - A phytochemical and pharmacological review

Authors

  • Yu Peng Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China
  • Hongxun Tao School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China
  • Wenjing Lu Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China
  • Xiaomin Cui Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China
  • Jing Hu Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China
  • Hui Ren Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China
  • Yuanqing Gao Jiangsu Provincial Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China
  • Yuanyuan Yang Xi’an Institute for Food and Drug Control, Xi’an, Shaanxi, China
  • Ye Li Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China
  • Zhiyong Chen Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China

Keywords:

Porana burm. f., traditional use, phytochemistry, network analysis, pharmacological activity

Abstract

There are about 20 species of Porana Burm. f. worldwide in tropical and subtropical Asia, Africa and neighboring islands, Oceania, and the Americas. In China, India, and other places, this genus enjoys a wealth of experience in folk applications. Nevertheless, the chemical composition of only five species has been reported, and 59 compounds have been isolated and identified, including steroids, coumarins, flavonoids, quinic acid derivatives, and amides. Pharmacological studies revealed that extracts from this genus and their bioactive components exhibit anti-inflammatory, analgesic, antioxidant, anti-gout, anti-cancer, and anti-diabetic effects. Although this genus is abundant, the development of its pharmacological applications remains limited. This review will systematically summarize the traditional and current uses, chemical compositions, and pharmacological activities of various Porana species. Network analysis was introduced to compare and confirm its output with current research progress to explore the potential targets and pathways of chemical components in this genus. We hope to increase understanding of this genus’s medicinal value and suggest directions for rational medicinal development. Keywords: Porana burm. f., traditional use, phytochemistry, network analysis, pharmacological activity

Author Biography

Yu Peng, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, Shaanxi, China

Jiangsu Provincial Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China

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