Preprint / Version 1

Biotechnological Intervention and Secondary Metabolite Production in Centella asiatica L.

Authors

  • Irfan Ganie Plant Biotechnology Laboratory, Department of Botany, Aligarh Muslim University, Aligarh 202002, India
  • Zishan Ahmad Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China
  • Anwar Shahzad Plant Biotechnology Laboratory, Department of Botany, Aligarh Muslim University, Aligarh 202002, India
  • Alexandra Zaushintsena Research Institute of Biotechnology, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia
  • Olga Neverova Department of Ecology and Nature Management, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia
  • Svetlana Ivanova Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia
  • Adla Wasi Plant Biotechnology Laboratory, Department of Botany, Aligarh Muslim University, Aligarh 202002, India
  • Sabaha Tahseen Plant Biotechnology Laboratory, Department of Botany, Aligarh Muslim University, Aligarh 202002, India

Keywords:

Centella asiatica, elicitation, hairy root culture, micropropagation, synthetic seeds, triterpenoids

Abstract

Centella asiatica L., commonly known as Gotu kola, Indian pennywort, and Asiatic pennyworts, is an herbaceous perennial plant that belongs to the family Apiaceae and has long been used in the traditional medicine system. The plant is known to produce a wide range of active metabolites such as triterpenoids including asiatic acid, asiaticoside, brahmoside, and madecassic acid along with other constituents including centellose, centelloside, and madecassoside, etc., which show immense pharmacological activity. Due to its beneficial role in neuroprotection activity, the plant has been considered as a brain tonic. However, limited cultivation, poor seed viability with low germination rate, and overexploitation for decades have led to severe depletion and threatened its wild stocks. The present review aimed to provide up-to-date information on biotechnological tools applied to this endangered medicinal plant for its in vitro propagation, direct or indirect regeneration, synthetic seed production, strategies for secondary metabolite productions including different elicitors. In addition, a proposed mechanism for the biosynthesis of triterpenoids is also discussed. Keywords: Centella asiatica, elicitation, hairy root culture, micropropagation, synthetic seeds, triterpenoids

Author Biographies

Zishan Ahmad, Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China

Bamboo Research Institute, Nanjing Forestry University, Nanjing 210037, China

Alexandra Zaushintsena, Research Institute of Biotechnology, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia

Department of Ecology and Nature Management, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia

Svetlana Ivanova, Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, Kemerovo 650043, Russia

Department of General Mathematics and Informatics, Kemerovo State University, Krasnaya Street, 6, Kemerovo 650043, Russia

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