Preprint / Version 1

Effects of Histone Modification in Major Depressive Disorder

Authors

  • Man-Si Wu Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, China;
  • Xiao-Juan Li Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, China;
  • Chen-Yue Liu Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing, China;
  • Qiuyue Xu Department of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China;
  • Jun-Qing Huang Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, China;
  • Simeng Gu Department of Psychology, Jiangsu University Medical School, Zhenjiang, China
  • Jia-Xu Chen Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, China;

Keywords:

Major depressive disorder, histone methylation, histone acetylation, histone phosphorylation, histone crotonylation, histone β-hydroxybutyrylation, HDAC inhibitor

Abstract

Major depressive disorder (MDD) is a disease associated with many factors; specifically, environmental, genetic, psychological, and biological factors play critical roles. Recent studies have demonstrated that histone modification may occur in the human brain in response to severely stressful events, resulting in transcriptional changes and the development of MDD. In this review, we discuss five different histone modifications, histone methylation, histone acetylation, histone phosphorylation, histone crotonylation and histone β-hydroxybutyrylation, and their relationships with MDD. The utility of histone deacetylase (HDAC) inhibitors (HDACis) for MDD treatment is also discussed. As a large number of MDD patients in China have been treated with traditional Chineses medicine (TCM), we also discuss some TCM therapies, such as Xiaoyaosan (XYS), and their effects on histone modification. In summary, targeting histone modification may be a new strategy for elucidating the mechanism of MDD and a new direction for MDD treatment. Keywords: Major depressive disorder, histone methylation, histone acetylation, histone phosphorylation, histone crotonylation, histone β-hydroxybutyrylation, HDAC inhibitor

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