Preprint / Version 1

Isolation and Bioassay of a New Terminalone A from Terminalia arjuna

Authors

  • Bushra Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan
  • Hamid Ullah Department of Chemistry, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta 87300, Pakistan
  • Mohamed El-Sayed Chemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia
  • Moamen Refat Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
  • Asma Al-Wasidi Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
  • Ahmed Naglah Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
  • Abdulrahman Almehizia Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
  • Dilfaraz Khan Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan
  • Khalil Rehman Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan
  • Shafiullah Khan Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan

Keywords:

Terminalia arjuna, Terminalone A, flavonoids, antibacterial, antioxidants, reactive oxygen specie

Abstract

Terminalia arjuna possesses significant cardioprotective, antidiabetic and antioxidant properties as these properties are described in Ayurveda. In the present study, three flavonoids were isolated through the separation and chromatographic purification of the whole plant material of T. arjuna. Spectroscopic characterization identified one of them as a new flavonoid “Terminalone A (1)” and two known flavonoids i.e., 6-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one (2) and 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (3). The bioactivity studies showed considerable antibacterial and antioxidant (DPPH radical scavenging) potential for all the three compounds 1–3 where the compound 1 showed strong antibacterial and antioxidant activity. Keywords: Terminalia arjuna, Terminalone A, flavonoids, antibacterial, antioxidants, reactive oxygen specie

Author Biographies

Hamid Ullah, Department of Chemistry, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta 87300, Pakistan

Writing – review & editing

Mohamed El-Sayed, Chemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia

Funding acquisition

Moamen Refat, Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

Funding acquisition

Asma Al-Wasidi, Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia

Funding acquisition

Ahmed Naglah, Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Funding acquisition

Abdulrahman Almehizia, Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Funding acquisition

Dilfaraz Khan, Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan

Formal analysis

Khalil Rehman, Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan

Supervision

Shafiullah Khan, Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan

Writing – original draft

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