Preprint / Version 1

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeoniaemodi Wall. ex Royle: current landscape and future perspectives

Authors

  • Nida Zahra Department of Biotechnology, University of Mianwali, Mianwali, 42200 Pakistan
  • Javad Sharifi-Rad Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
  • Alibek Ydyrys Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, 050040 Almaty, Kazakhstan
  • Tabassum Yaseen Department of Botany, Bacha Khan University, Charsadda, Khyber Pakhtunkhwa Pakistan
  • Ayesha Nawaz National Institute of Genomics and Advanced Biotechnology (NIGAB), National Agricultural Research Center (NARC), Park Road, Islamabad, Pakistan
  • Hassan Sher Center for Plant Sciences and Biodiversity, University of Swat, Kanju, 19201 Pakistan
  • Banzeer Abbasi Department of Botany, Rawalpindi Women University, 6th Road, Satellite Town, Rawalpindi, 46300 Pakistan
  • Muhammad Arif Department of Biotechnology, University of Mianwali, Mianwali, 42200 Pakistan
  • Javed Iqbal Department of Botany, Bacha Khan University, Charsadda, Khyber Pakhtunkhwa Pakistan
  • Daniela Calina Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania

Keywords:

Paeoniaemodi, Traditional uses, Phytochemistry, Pharmacological activities

Abstract

Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance as a food and medicine. The practice of Paeonia emodi Wall. ex Royle is very ancient and it is conventionally used for a wide range of illnesses in the folk system of medicine because of its wide beneficial phytochemical profile. The main purpose of the current review was the synthesis of recent data on botany, ethnopharmacology, phytochemistry and potential pharmacological mechanisms of action of Paeonia emodi Wall. ex Royle, thus offering new prospects for the development of new adjuvant natural therapies. Using scientific databases such as PubMed/MedLine, Scopus, Web of Science, ScienceDirect, Google Scholar, Springer, and Wiley, a comprehensive literature search was performed for Paeonia emodi Wall. ex Royle. For searching, we used the next MeSH terms: “Biological Product/isolation and purification”, “Biological Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. The results of the most recent studies were analyzed and the most important data were summarized in tables and figures. Phytochemical research of Paeonia emodi Wall. ex Royle has led to the isolation of triterpenes, monoterpenes, phenolic acids, fatty acids, organic compounds, steroids, free radicals and some other classes of primary metabolites. In addition, diverse pharmacological activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase and beta-glucuronidase inhibiting activity, radical scavenging activity, phytotoxic and insecticidal activities have been reported for Paeonia emodi Wall. ex Royle. Different bioactive compounds of Paeonia emodi Wall. ex Royle has proven their therapeutic potential in modern pharmacological and biomedical research to cure numerous gastrointestinal and nervous disorders. In future, further in vitro and in vivo therapeutic studies are required to identify new mechanisms of action, pharmacokinetics studies, and new pharmaceutical formulations for target transport and possible interaction with allopathic drugs. Also, new research regarding quality evaluation, toxicity and safety data in humans is needed. Keywords: Paeoniaemodi, Traditional uses, Phytochemistry, Pharmacological activities

Author Biography

Alibek Ydyrys, Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, 050040 Almaty, Kazakhstan

The Elliott School of International Affairs, George Washington University, 1957 E St NW, Washington, DC 20052 USA

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