Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives
Authors
Satish Dubey
Laboratory of Molecular Taxonomy & Medicinal Plant Biology, Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur 495009, Chhattisgarh, India
Ashwini Dixit
Laboratory of Molecular Taxonomy & Medicinal Plant Biology, Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur 495009, Chhattisgarh, India
The disruptions in skin integrity contribute to its disorientation, and tissue annihilations result in acute or chronic wound formation. Polyherbal formulations are widely used in traditional systems of mecdicine like ayurveda for wound healing. The combination of these traditional therapies with clinical therapies has helped in the development of various wound-healing products.
Method
In this systematic review, the therapeutic potency of several polyherbal formulations from different medicinal floras is summed together in response to their impact on wound healing. The literature search was performed on Pubmed, Scopus, and ScienceDirect databases between 2010–2020. PRISMA methodology was applied to extract relevant information about polyherbal formulations.
Result
A total of 54 articles were selected under all themes for the data extraction as per the PRISMA guidelines. These 54 articles have high-quality scores ≥3. Forty-three records were used for the narrative analysis, while nine records were used for the critical analysis in the narrative review. Further, theme-wise key data sets were screened from the selected literature and summarized in a tabular form. Bibliometric analysis of the Scopus database has also drawn attention to limited academic literature showcasing randomized clinical trials in the current subject. Most of these polyherbal formulations are tested in laboratory-scale studies, thus portraying further research options.
Conclusion
Polyherbal formulations are effective in promoting the wound-healing process. They can stimulate a variety of physiological functions that accelerates the process of healing. These formulations merit further investigation in clinical trials, and production up scaling will aid in the creation of a new horizon of polyherbal wound healing products.
Keywords: Medicinal plants, Pharmacological activity, Polyherbal formulations, Systematic review, Wound healing
Abbreviations: PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; CASP, Critical Appraisal skills Programme; RQ1, Research Question 1; RQ2, Research Question2; RQ3, Research Question 3; WHO, World Health Organization
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