Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial
Authors
Vijaya Majumdar
Division of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, Karnataka 560105 India
N Manjunath
Division of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, Karnataka 560105 India
Atmakur Snigdha
Division of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, Karnataka 560105 India
Prosenjeet Chakraborty
Division of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, Karnataka 560105 India
Robin Majumdar
Indian Institute of Information Technology, Bangalore, Karnataka 560100 India
Keywords:
Biological age, Yoga, Aging
Abstract
Introduction
The recent development of robust indices to quantify biological aging, along with the dynamic epidemiological transitions of population aging generate the unmet need to examine the extent up to which potential interventions can delay, halt or temporarily modulate aging trajectories.
Methods and analysis
The study is a two-armed, open label randomised controlled trial. We aim to recruit 166 subjects, aged 60–75 years from the residential communities and old age clubs in Bangalore city, India, who will undergo randomisation into intervention or control arms (1:1). Intervention will include yoga sessions tailored for the older adults, 1 h per day for 5 days a week, spread for 12 months. Data would be collected at the baseline, 26th week and 52nd week. The primary outcome of the study is estimation in biological age with yoga practice. The secondary outcomes will include cardinal mechanistic indicators of aging- telomere length, interleukin-6 (IL-6), tumor necrosis factor receptor II (TNF-RII), high sensitivity c-reactive protein (hsCRP)], insulin signaling [insulin and IGF1], renal function [cystatin], senescence [growth differentiating factor 15 (GDF-15)] and cardiovascular function [N-terminal B-type natriuretic peptides (NT-proBNP)]. Analyses will be by intention-to-treat model.
Ethics & dissemination
The study is approved by the Institutional Ethics Committee of Swami Vivekananda Yoga Anusandhana Samsthana University, Bangalore (ID:RES/IEC-SVYASA/242/2022). Written informed consent will be obtained from each participant prior to inclusion.
Trial registration number
CTRI/2022/07/044442.
Keywords: Biological age, Yoga, Aging
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