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3‴-O-Foliamenthoyl-Rutin, a New Flavonoid Glycoside from the Roots of Nymphoides peltata

Authors

Keywords:

Salix chaenomeloides, phenolic glycoside, chaenomelin, Helicobacter pylori

Abstract

Nymphoides peltata (Menyanthaceae) has been used as a medicinal herb in traditional medicines to treat conditions such as strangury, polyuria, swelling, and as a diuretic and antipyretic. In our ongoing research to discover novel structural and/or biological natural products in natural resources, five flavonoids, quercetin (1), quercitrin (2), isoquercetin (3), quercetin-3-O-vicianoside (4), and rutin (5), as well as a new flavonoid glycoside, 3‴-O-foliamenthoyl-rutin (6), were isolated from the MeOH extract of N. peltata roots. The chemical structure of the new compound (6) was determined by analyzing 1D and 2D NMR spectra and high-resolution (HR) electrospray ionization mass spectroscopy (ESIMS), along with a chemical reaction. The wound-healing activities of the isolated compounds (1–6) were evaluated using a HaCaT cell scratch test. Among the isolates, isoquercetin (3), quercetin-3-O-vicianoside (4), and 3‴-O-foliamenthoyl-rutin (6) promoted HaCaT cell migration over scratch wounds, with compound 4 being the most effective. Our findings provide experimental data supporting the potential of quercetin-3-O-vicianoside (4) as a wound-healing agent. Keywords: Salix chaenomeloides, phenolic glycoside, chaenomelin, Helicobacter pylori

Author Biographies

Tae-Young Kim, Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea; [email protected] (T.-Y.K.); [email protected] (B.-G.J.); [email protected] (M.-J.K.); [email protected] (T.-H.K.)

Methodology

Bum Lee, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea; [email protected]

Methodology

Beom-Geun Jo, Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea; [email protected] (T.-Y.K.); [email protected] (B.-G.J.); [email protected] (M.-J.K.); [email protected] (T.-H.K.)

Methodology

Seong Heo, Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea; [email protected]

Methodology

Min-Ji Keem, Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea; [email protected] (T.-Y.K.); [email protected] (B.-G.J.); [email protected] (M.-J.K.); [email protected] (T.-H.K.)

Methodology

Taek-Hwan Kwon, Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea; [email protected] (T.-Y.K.); [email protected] (B.-G.J.); [email protected] (M.-J.K.); [email protected] (T.-H.K.)

Methodology

Su-Nam Kim, Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea; [email protected]

Conceptualization

Ki Kim, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea; [email protected]

Conceptualization

Min Yang, Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea; [email protected] (T.-Y.K.); [email protected] (B.-G.J.); [email protected] (M.-J.K.); [email protected] (T.-H.K.)

Conceptualization

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