Preprint / Version 1

Phytoimmunomodulators: A review of natural modulators for complex immune system

Authors

  • Partibha Hooda aDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India
  • Rohit Malik bGurugram Global College of Pharmacy, Gurugram, India
  • Saurabh Bhatia dSchool of Health Science, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India
  • Ahmed Al-Harrasi eNatural & Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, Oman
  • Asim Najmi fDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi Arabia
  • Khalid Zoghebi fDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi Arabia
  • Maryam Halawi gDepartment of Clinical pharmacy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi Arabia
  • Hafiz Makeen gDepartment of Clinical pharmacy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi Arabia
  • Syam Mohan hSubstance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia

Keywords:

Phytoimmunomodulators, Secondary metabolites, Ayurveda, Traditional Chinese medicine, COVID-19, Immunomodulators

Abstract

In the past few decades, the medicinal properties of plants and their effects on the human immune system are being studied extensively. Plants are an incredible source of traditional medicines that help cure various diseases, including altered immune mechanisms and are economical and benign compared to allopathic medicines. Reported data in written documents such as Traditional Chinese medicine, Indian Ayurvedic medicine support the supplementation of botanicals for immune defense reactions in the body and can lead to safe and effective immunity responses. Additionally, some botanicals are well-identified as magical herbal remedies because they act upon the pathogen directly and help boost the immunity of the host. Chemical compounds, also known as phytochemicals, obtained from these botanicals looked promising due to their effects on the human immune system by modulating the lymphocytes which subsequently reduce the chances of getting infected. This paper summarises most documented phytochemicals and how they act on the immune system, their properties and possible mechanisms, screening conventions, formulation guidelines, comparison with synthetic immunity-enhancers, marketed immunity-boosting products, and immune-booster role in the ongoing ghastly corona virus wave. However, it focuses mainly on plant metabolites as immunomodulators. In addition, it also sheds light on the current advancements and future possibilities in this field. From this thorough study, it can be stated that the plant-based secondary metabolites contribute significantly to immunity building and could prove to be valuable medicaments for the design and development of novel immunomodulators even for a pandemic like COVID-19. Keywords: Phytoimmunomodulators, Secondary metabolites, Ayurveda, Traditional Chinese medicine, COVID-19, Immunomodulators

Author Biographies

Rohit Malik, bGurugram Global College of Pharmacy, Gurugram, India

cSRM Modi Nagar College of Pharmacy, SRMIST, Delhi-NCR Campus, Ghaziabad, India

Saurabh Bhatia, dSchool of Health Science, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India

eNatural & Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, Oman

Syam Mohan, hSubstance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia

iCenter for Global health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India

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