Preprint / Version 1

Nootropic activity of methanolic extract from Evolvulus alsinoides Linn. in mice with scopolamine-induced amnesia

Authors

  • Karnam Nithya Department of Pharmacology, Vinayaka Missions University, Salem (Deemed to be university), Chinna Seeragapadi, Salem - 636308, Tamilnadu, India
  • Rajaram Siddaraman Department of Pharmacology, VMKV Medical College, Chinna Seeragapadi, Salem - 636308, Tamil Nadu, India
  • PP Sheelajoice Department of Physiology, VMKV Medical College, Chinna Seeragapadi, Salem - 636 308, Tamil Nadu, India
  • Mani Rajarathinam Department of Pharmacology, GMKMC Medical College, Shavapet Salem 636002, Tamil Nadu, India
  • Vurimi Chandra Department of Pharmacology, Narayana Medical College, Nellore - 524 003, AP, India

Keywords:

Nootropic activity, methanolic extract, Evolvulus alsinoides Linn, vishnukranthi, scopolamine

Abstract

Plants have been used as therapeutic agents in both un-ionized (Unani, Ayurveda) and unstructured forms since ancient times. Therefore, it is of interest to document the nootropic activity of methanolic extract from Evolvulus alsinoides Linn (Vishnukranthi) in mice with scopolamine-induced amnesia. Healthy male Swiss albino mice ranging between 25 and 30 g were used in the study. Scopolamine induced amnesia, the following two tests are performed, elevated plus maze test, passive avoidance test. The mean time spent in the open arm, closed arm, and central platform for each group of animals. The total transitions were 12.6±0.89 by GS group mice, 3.4±0.55 by GSP group mice, 7±0.71 by GSLD group mice and 10±0.71 by GSHD group mice. A significant difference was seen between GS and GSP group mice means. The mean time in the safe zone and shock zone for each group of animals when comparing to Group 2 Vs Group 3, 4 showed a statistical significance of p < 0.05. The findings of this study suggest that Evolvulus alsinoides may be a promising candidate for the development of new treatments for memory impairment and other cognitive disorders. It should be noted that more data is needed to confirm the safety and efficacy of Evolvulus alsinoides in humans and to investigate its long-term effects. Keywords: Nootropic activity, methanolic extract, Evolvulus alsinoides Linn, vishnukranthi, scopolamine

Downloads