Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products
Authors
Tenzin Jamtsho
College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Karma Yeshi
College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Matthew Perry
College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Alex Loukas
Australian Institute of Tropical Health, and Medicine (AITHM), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected]
Phurpa Wangchuk
College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Keywords:
natural products, biodiscovery approaches and strategies, anti-inflammatory drug lead molecules, isolation techniques, medicinal plants, parasitic helminths
Abstract
Natural products (NPs) have played a vital role in human survival for millennia, particularly for their medicinal properties. Many traditional medicine practices continue to utilise crude plants and animal products for treating various diseases, including inflammation. In contrast, contemporary medicine focuses more on isolating drug-lead compounds from NPs to develop new and better treatment drugs for treating inflammatory disorders such as inflammatory bowel diseases. There is an ongoing search for new drug leads as there is still no cure for many inflammatory conditions. Various approaches and technologies are used in drug discoveries from NPs. This review comprehensively focuses on anti-inflammatory small molecules and describes the key strategies in identifying, extracting, fractionating and isolating small-molecule drug leads. This review also discusses the (i) most used approaches and recently available techniques, including artificial intelligence (AI), (ii) machine learning, and computational approaches in drug discovery; (iii) provides various animal models and cell lines used in in-vitro and in-vivo assessment of the anti-inflammatory potential of NPs.
Keywords: natural products, biodiscovery approaches and strategies, anti-inflammatory drug lead molecules, isolation techniques, medicinal plants, parasitic helminths
Author Biographies
Tenzin Jamtsho, College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Australian Institute of Tropical Health, and Medicine (AITHM), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected]
Karma Yeshi, College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Australian Institute of Tropical Health, and Medicine (AITHM), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected]
Matthew Perry, College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Australian Institute of Tropical Health, and Medicine (AITHM), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected]
Phurpa Wangchuk, College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected] (K.Y.); [email protected] (M.J.P.)
Australian Institute of Tropical Health, and Medicine (AITHM), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia; [email protected]
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