Preprint / Version 1

The therapeutic effect of traditional Chinese medicine on breast cancer through modulation of the Wnt/β-catenin signaling pathway

Authors

  • Hongkun Li College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Jiawei Li College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Yifan Zhang College of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Chengcheng Zhao Experimental Teaching and Practical Training Center, Heilongjiang University of Chinese Medicine, Harbin, China
  • Jun Ge College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Yujiao Sun College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Hui Fu College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • Yingpeng Li College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Keywords:

breast cancer, Wnt/β-catenin signaling pathway, traditional Chinese medicine, chemotherapy drugs, therapeutic approach

Abstract

Breast cancer, the most prevalent malignant tumor among women globally, is significantly influenced by the Wnt/β-catenin signaling pathway, which plays a crucial role in its initiation and progression. While conventional chemotherapy, the standard clinical treatment, suffers from significant drawbacks like severe side effects, high toxicity, and limited prognostic efficacy, Traditional Chinese Medicine (TCM) provides a promising alternative. TCM employs a multi-targeted therapeutic approach, which results in fewer side effects and offers a high potential for effective treatment. This paper presents a detailed analysis of the therapeutic impacts of TCM on various subtypes of breast cancer, focusing on its interaction with the Wnt/β-catenin signaling pathway. Additionally, it explores the effectiveness of both monomeric and compound forms of TCM in the management of breast cancer. We also discuss the potential of establishing biomarkers for breast cancer treatment based on key proteins within the Wnt/β-catenin signaling pathway. Our aim is to offer new insights into the prevention and treatment of breast cancer and to contribute to the standardization of TCM. Keywords: breast cancer, Wnt/β-catenin signaling pathway, traditional Chinese medicine, chemotherapy drugs, therapeutic approach

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