Preprint / Version 1

Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis

Authors

  • Paulo Juiz Center for Science and Technology in Energy and Sustainability, Federal University of Recôncavo da Bahia, Feira de Santana 44042-280, BA, Brazil; [email protected] (P.J.L.J.); [email protected] (L.T.B.F.)
  • Luiza Ferreira Center for Science and Technology in Energy and Sustainability, Federal University of Recôncavo da Bahia, Feira de Santana 44042-280, BA, Brazil; [email protected] (P.J.L.J.); [email protected] (L.T.B.F.)
  • Edilson Pires Faculty of Education and Integrated Sciences of Sertão de Canindé, State University of Ceará, Canindé 62700-000, CE, Brazil; [email protected]
  • Cristiane Villarreal School of Pharmacy, Federal University of Bahia, Salvador 40170-290, BA, Brazil

Keywords:

antioxidant, periodontal disease, phytochemical

Abstract

Periodontal disease is an inflammatory condition characterized by an aberrant immune response against a dysbiotic dental biofilm, with oxidative stress performing an essential role in its pathogenesis. This paper presents a patent mining, performed in the Orbit Intelligence patent database, related to antioxidant phytochemicals in the technological developments that are working to prevent and treat periodontal disease. To access the documents, the descriptors “PERIODONTAL” and “ANTIOXIDANT” were typed in the title, abstract, and claim search fields. A total of 322 patents demonstrate the growing interest in researching natural antioxidants for scientific and technological purposes. The top ten countries regarding the number of family patents produced were the United States, the European Office, Japan, South Korea, China, India, Mexico, Denmark, Canada, and Great Britain. The most cited compounds were vitamin C, green tea, quercetin, melatonin, lycopene, resveratrol, and curcumin. These compounds have been used for the technological development of gels, membranes, dentifrices, chewing gum, orally disintegrating film, mouthwash, mouth spray, and mouth massage cream and exhibit the ability to neutralize free radicals and reduce oxidative stress, a critical factor in the development and progression of periodontal diseases. The patent documents have shown that using antioxidant compounds in conjunction with traditional periodontal treatments is a promising area of interest in periodontal therapy. Keywords: antioxidant, periodontal disease, phytochemical

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