Preprint / Version 1

Characterization of Rhodiola heterodonta (Crassulaceae): Phytocomposition, Antioxidant and Antihyperglycemic Activities

Authors

  • Zaripova MR Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan
  • Gayibova SN Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan
  • Makhmudov RR Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan
  • Mamadrahimov AA Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan
  • Vypova NL Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan
  • Gayibov UG Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan
  • Miralimova SM Institute of Microbiology, Academy of Science of Uzbekistan, Tashkent 100128, Uzbekistan
  • Aripov TF Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan

Keywords:

alphα-amylase, alphα-glucosidase, antioxidants, hypoglycemic agents, qualitative/quantitative determination of compounds

Abstract

Plant extracts have been widely used in traditional medicine to prevent diabetes. The present study aimed to examine the antihyperglycemic properties of an ethanolic extract from Rhodiola heterodonta roots. In vitro evaluation revealed that treatment with the R. heterodonta extract resulted in significant reactive oxygen species inhibition, glucose binding, glucose transporter activation, and suppression of α-amylase and α-glucosidase. Moreover, the treatment with 100 mg/kg of R. heterodonta extract dramatically decreased glucose levels in glucose-, alloxan-, or adrenaline-induced diabetic rats. The information gathered in this study bridges the knowledge gap between traditional healers in Uzbekistan who utilize R. heterodonta and its potential for future medication development. Keywords: alphα-amylase, alphα-glucosidase, antioxidants, hypoglycemic agents, qualitative/quantitative determination of compounds

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