Preprint / Version 1

Multi-targeted therapeutic exploration of Tamarix gallica flowers for anti-ulcer activity and associated complications

Authors

  • Aakash Jaiswal aSchool of Pharmaceutical Sciences, IIMT University, O Pocket, Ganga Nagar, 250001, Meerut, Uttar Pradesh, India
  • Yasheshwar Yasheshwar bDepartment of Botany, Acharya Narendra Dev College (University of Delhi), Govindpuri, Kalkaji, New Delhi, 110019, India
  • Sapna Salar cBBDIT College of Pharmacy, Ghaziabad, 201206, Uttar Pradesh, India
  • Shamim Shamim dDepartment of Pharmacy, IIMT College of Medical Sciences, IIMT University, O Pocket, Ganga Nagar, 250001, Meerut, Uttar Pradesh, India
  • Dinesh Yadav eDepartment of Pharmacognosy, SGT College of Pharmacy, SGT University, Gurugram, 122505, Haryana, India
  • Mansi Aggarwal aSchool of Pharmaceutical Sciences, IIMT University, O Pocket, Ganga Nagar, 250001, Meerut, Uttar Pradesh, India
  • Shalini Sharma fSunder Deep Pharmacy College, NH-9, Delhi- Meerut Expressway, Dasna, 201002, Ghaziabad, Uttar Pradesh, India
  • Rustam Ekbbal dDepartment of Pharmacy, IIMT College of Medical Sciences, IIMT University, O Pocket, Ganga Nagar, 250001, Meerut, Uttar Pradesh, India
  • Gaurav Gaurav dDepartment of Pharmacy, IIMT College of Medical Sciences, IIMT University, O Pocket, Ganga Nagar, 250001, Meerut, Uttar Pradesh, India

Keywords:

Peptic ulcer, Tamarix gallica, Aspirin, Network pharmacology, Antioxidant activity, Anti-ulcer activity

Abstract

Background: Peptic ulcer is a condition characterized by open sores resulting from excessive acid production in the stomach or digestive tract, causing damage to the mucosal lining. Tamarix gallica (TG), is traditionally known for its anti-inflammatory, antioxidant, antibacterial activity, etc. Objective: The scientific evidences based on its efficacy specifically for anti-ulcers activity are limited, hence, the study aimed to evaluate protective effect of TG against aspirin-induced peptic ulcers. Materials and Methods: Phytochemical screening was performed followed by assessment of protective effect of TG against aspirin induced toxicity in rats. Network biology and polypharmacology studies were performed to determine the possible molecular targets involved in pathophysiology of ulcers. Results: The study revealed that the TG extract at high dose (500 mg/kg b.w.) significantly exhibits protective effect against aspirin induced ulcers via regulation of free acidity pepsin production, overall acidity via regulating antioxidant status (SOD, GSH, CAT, etc). Morphological studies revealed less damage with less disruption of the gastric mucosa layer having normal mucosal structure, no swelling or oedema was found in drug treated groups. Conclusion: Moreover, network biology and polypharmacology outcomes revealed that SOD2, CAT, EPO, IL10, EGF, TGFB1 etc. play a significant role in functional gastrointestinal-associated disease or peptic ulcer. Hence, the study concludes that TG polyphenols including phenols and flavonoids play an important role in alleviation of peptic ulcer or associated complication and thus demonstrating TG as a natural therapeutic regimen against ulcers in glance of nature. Keywords: Peptic ulcer, Tamarix gallica, Aspirin, Network pharmacology, Antioxidant activity, Anti-ulcer activity

Author Biography

Gaurav Gaurav, dDepartment of Pharmacy, IIMT College of Medical Sciences, IIMT University, O Pocket, Ganga Nagar, 250001, Meerut, Uttar Pradesh, India

gDepartment of Research and Development, Hamdard Laboratories (India), Factory-B-1/2/3, Industrial Area, Meerut Road, Ghaziabad, 201003, Uttar Pradesh, India

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