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Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in India: A Convergent Parallel Mixed Methods Study

Authors

  • Anubha MSc Division of Cardiology, Department of Medicine and Global Health Center, Washington University in St. Louis, St. Louis, MO, USA
  • Raji MSc Global Antibiotic Research and Development Partnership, New Delhi, Delhi, India
  • Salva PhD Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  • Aashima MPH Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  • Dorairaj DM Centre for Chronic Disease Control, New Delhi, Delhi, India
  • Mark MPH Division of Cardiology, Department of Medicine and Global Health Center, Washington University in St. Louis, St. Louis, MO, USA
  • Lisa MPH Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  • Padinhare DM WestFort Hi-Tech Hospital, Thrissur, Kerala, India

Keywords:

heart failure with reduced ejection fraction, India, mixed methods

Abstract

Introduction: A polypill-based implementation strategy has been proposed to increase rates of guideline-directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction. This has the potential to improve mortality and morbidity in India and undertreated populations globally. Methods: We conducted a convergent parallel mixed methods study integrating quantitative data from stakeholder surveys using modified implementation science outcome measures and qualitative data from key informant in-depth interviews. Our objective was to explore physician, nurse, pharmacist, and patient perspectives on a HFrEF polypill implementation strategy in India from January 2021 to April 2021. Quantitative and qualitative data were integrated to develop an Implementation Research Logic Model. Results: Among 69 respondents to the stakeholder survey, there was moderate acceptability (mean [SD] 3.8 [1.0]), appropriateness (3.6 [1.0]), and feasibility (3.7 [1.0]) of HFrEF polypill implementation strategy. Participants in the key-informant in-depth interviews (n = 20) highlighted numerous relative advantages of the HFrEF polypill innovation including potential to simplify medication regimens and improve patient adherence. Key relative disadvantages elucidated, include concerns about side effects and interruption of multiple GDMT medications due to polypill discontinuation for side effects or hospitalizations. Based on this data, the proposed implementation strategies in the Implementation Research Logic Model include 1) HFrEF polypills, 2) HFrEF polypill initiation, titration, and maintenance protocols, and 3) HFrEF polypill laboratory monitoring protocols for safety which we postulate will lead to desired clinical and implementation outcomes through multiple mechanisms including increased medication adherence to a single pill. Conclusion: This study demonstrates that a HFrEF polypill-based implementation strategy is considered acceptable, feasible, and appropriate among healthcare providers in India. We identified contextually relevant determinants, strategies, mechanism, and outcomes outlined in an Implementation Research Logic Model to inform future research to improve heart failure care in South Asia. Keywords: heart failure with reduced ejection fraction, India, mixed methods

Author Biographies

Salva PhD , Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Center of Innovation for Complex Chronic Healthcare, Health Services Research and Development, Edward Hines, Jr. Veterans Affairs Hospital, Hines, IL, USA

Mark MPH , Division of Cardiology, Department of Medicine and Global Health Center, Washington University in St. Louis, St. Louis, MO, USA

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia

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