Harnessing the nutriceutics in early-stage breast cancer: mechanisms, combinational therapy, and drug delivery
Authors
Pavithra Prabhu
Nitte (Deemed to Be University), Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Mangaluru, 575018 India
Akhilesh Dubey
Nitte (Deemed to Be University), Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Mangaluru, 575018 India
Ivan Mijakovic
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
Manohar Mahadev
Nitte (Deemed to Be University), Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Mangaluru, 575018 India
Haribalan Perumalsamy
Center for Creative Convergence Education, Hanyang University, Seoul, Republic of Korea
Amitha Shetty
Nitte (Deemed to Be University), Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Mangaluru, 575018 India
Sri Balusamy
Department of Food Science and Biotechnology, Sejong University, Gwangjin-Gu, Seoul, Republic of Korea
Cynthia Lobo
Nitte (Deemed to Be University), Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Mangaluru, 575018 India
Barsha Mohanty
Nitte (Deemed to Be University), Department of Molecular Genetics and Cancer Biology, Nitte University Centre for Science, Education and Research, Mangaluru, 575018 India
Priyanka Singh
Systems and Synthetic Biology Division, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden
Keywords:
Breast cancer, Chemotherapy, Dietary phytomolecules, Nutrition-based combination therapy, Complementary and alternative system of medicine, Novel drug delivery systems
Abstract
Breast cancer (BC) is a significant health challenge, ranking as the second leading cause of cancer-related death and the primary cause of mortality among women aged 45 to 55. Early detection is crucial for optimal prognosis. Among various treatment options available for cancer, chemotherapy remains the predominant approach. However, its patient-friendliness is hindered by cytotoxicity, adverse effects, multi-drug resistance, potential for recurrence, and high costs. This review explores extensively studied phytomolecules, elucidating their molecular mechanisms. It also emphasizes the importance of combination therapy, highlighting recent advancements in the exploration of diverse drug delivery systems and novel routes of administration. The regulatory considerations are crucial in translating these approaches into clinical practices.
Results
Consequently, there is growing interest in exploring the relationship between diet, cancer, and complementary and alternative medicine (CAM) in cancer chemotherapy. Phytochemicals like berberine, curcumin, quercetin, lycopene, sulforaphane, resveratrol, epigallocatechin gallate, apigenin, genistein, thymoquinone have emerged as promising candidates due to their pleiotropic actions on target cells through multiple mechanisms with minimal toxicity effects. This review focuses on extensively studied phytomolecules, elucidating their molecular mechanisms. It also emphasizes the importance of combination therapy, highlighting recent advancements in the exploration of diverse drug delivery systems and novel routes of administration. The regulatory considerations are crucial in translating these approaches into clinical practices.
Conclusion
The present review provides a comprehensive understanding of the molecular mechanisms, coupled with well-designed clinical trials and adherence to regulatory guidelines, which pave the way for nutrition-based combination therapies to become a frontline approach in early-stage BC treatment.
Graphical Abstract
Keywords: Breast cancer, Chemotherapy, Dietary phytomolecules, Nutrition-based combination therapy, Complementary and alternative system of medicine, Novel drug delivery systems
Author Biography
Haribalan Perumalsamy, Center for Creative Convergence Education, Hanyang University, Seoul, Republic of Korea
Research Institute for Convergence of Basic Science, Hanyang University, Seoul 04763, South Korea, Hanyang University, Seoul, Republic of Korea
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